Response of Experimental Retinal Neovascularization to Thiazolidinediones

Response of experimental retinal neovascularization to thiazolidinediones.

OBJECTIVE To determine the effect of thiazolidinediones (TZDs) on experimental retinal neovascularization. METHODS The ability of the TZDs troglitazone and rosiglitazone maleate (1-20 micromol/L) to inhibit retinal endothelial cell (REC) proliferation, migration, tube formation, and signaling was determined in response to vascular endothelial growth factor (VEGF). In vivo studies were perform...

[Neovascularization in experimental retinal venous obstruction in rabbit].

Experimental retinal venous obstruction was produced in rabbit eyes by transadventitial instillation of thrombin for the purpose of studying the late stage of histopathological changes in the retina. Three months after the instillation, abnormal vessels and compensatory shunt vessels were observed by ophthalmoscopy. Capillary obstruction, blood leakage from venules and neovascularization were o...

Squalamine improves retinal neovascularization.

PURPOSE Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model. METHODS OIR was induced in C57BL6 mice by a 5-day exposure to 75% oxygen from postnatal day (P)7 through P12. Squalamine (25 mg/kg, subcutan...

Mechanisms of retinal and choroidal neovascularization.

Retinal Microvascular Response to Short-Term Exposure to Particulate Matters As an Indicator of Cardiovascular Effects in Work Environments

Introduction: According to the literature, Central Retinal Arteriolar Equivalent (CRAE), Central Retinal Venular Equivalent (CRVE), and Artemio Venule Ratio (AVR) are three important markers in determining the changes of retinal artery. These markers are employed as an indicator of cardiovascular effects in workers. This study aimed to evaluate the changes in retinal micro vascular responses in...